First off, please go by and read That Paleo Guy's account of being in the middle of the latest Christchurch earthquake. Fortunately he and his loved ones and cat are all okay. You can also follow his twitter feed here. I've never been at the epicenter of disaster, and I don't know that I would have acquitted myself quite so well. I mean, once when I was in college our power...
Minggu, 27 Februari 2011
Jumat, 25 Februari 2011
Lithium and Longevity
Posted on 13.27 by chorili
A new paper was published this week - Low-dose lithium uptake promotes longevity in humans and metazoans. Now, as a psychiatrist, I'm a lithium fan. Apparently, it is an essential trace micronutrient (who knew) aside from the uses for decreasing suicide and helping mood stabilization. Want a primer - look at my blog post here. (Here is the original lithium for treating mania paper...
Sabtu, 19 Februari 2011
Basic Science - Energy is Everything
Posted on 17.49 by chorili

Let's review. Some 9 months ago, an excitable young psychiatrist of reasonable pedigree launched Evolutionary Psychiatry as a means to explore how the differences between our modern lives and diets compared to traditional/evolutionary experiences may influence the generation of mental illness. To that end she peeled back the edges of several...
Jumat, 18 Februari 2011
Healthy Skepticism
Posted on 12.09 by chorili
Among the papers from the last post fell out this letter in Science, The Potential of Nutritional Therapy. (unfortunately, limited access). However, the letter speaks to many of the shortcomings in investigating the science of nutritional cures, and has a number of important points. Conventional adherents might find this odd, but these shortcomings are, in part, why I hold fast to a "paleolithic-style"...
Selasa, 15 Februari 2011
Mental Health and Omega 3/6 Ratio, A New Review
Posted on 18.43 by chorili
Twitter is a black hole for time spitting out information like Hawking radiation. (I may have achieved the geekiest simile ever!) I've been a bit busy, as the applications for preschool are pretty detailed, asking for medical records, descriptions of my culture, and different ways we help the little one settle down or take her nap (bribery and...
Kamis, 10 Februari 2011
The Neurobiology of Insomnia - How I Learned to *Start* Worrying and Love Orexin
Posted on 13.35 by chorili
The sleep and insomnia literature is vast enough to make one... well, overwhelmed. New textbooks, then, can be a nice resource. But textbooks are a bit of a gamble - some are fantastic, and others are disorganized and hideously boring. Like the one I'm reading now. But I spent some $$ and I'm powering through. (Today we're in chapter 7, pages 68-82) Insomnia. There...
Rabu, 09 Februari 2011
Some Thoughts and Some Tchaikovsky
Posted on 17.14 by chorili

Certain composers seem to be able to understand the music that floats in the air between molecules, the music that describes the light, wind, war, and love. Tchaikovsky can be a bit too romantic, as the Russian composers were apt to be (a writer would call it purple prose), but in my mind there are few better songs than the 1812 Overture (right click...
Sabtu, 05 Februari 2011
Food Elimination Diet and ADHD
Posted on 10.18 by chorili
There is little argument that diet has a contribution in the major diseases of civilization, such as heart disease and type II diabetes. However, the effect of diet on mental health disorders remains controversial in the conventional circles. I'm not entirely clear why, as it has been known for a decade or more that different kinds of inflammation mediate both metabolic syndrome and the...
Kamis, 03 Februari 2011
Sad Monkeys Hopped Up on Omega 6 PUFAs
Posted on 19.06 by chorili
Today, the amazing Victoria sent me a paper that is way too great to pass up: Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet*I know, it's monkeys, not humans. But these researchers actually took the connection between diet, cardiovascular disease, and depression seriously, and found a reasonable animal model that covered everything. More or less. ...
Rabu, 02 Februari 2011
Appetite Regulation and the Brain
Posted on 16.05 by chorili
Before we get back to sleeping, there's a bit of brain signaling that it is important to get a handle on. Most of this information is derived from rodent studies, but I have no reason to believe their brain signaling about appetite and whatnot would be much different from our own. I want to go over this bit about satiety and hunger pathways in the brain because they overlap with the sleep...
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